Research progress on immunoglobulin of yolk in the prevention and treatment of aquatic animal diseases

doi:10.14012/j.cnki.fjsc.2024.02.010

Abstract

Abstract:

Yolk immunoglobulin (IgY), a polyclonal antibody, has garnered considerable attention for its role in conferring passive immunity against bacterial and viral diseases. This paper comprehensively reviews the current research on the fundamental structure and physicochemical properties of IgY. Additionally, the paper emphasize the diverse applications of IgY in preventing and treating bacterial and viral diseases, offering valuable insights for future research and the broader utilization of IgY in aquaculture.

Key words: immunoglobulin of yolk, passive immunity, aquatic animal diseases

摘要：

卵黄抗体(Immunoglobulin of yolk, IgY)因在水生动物疾病中具有被动免疫疗效而受到广泛的关注。本文综述了IgY基本结构和理化性质的研究进展,重点介绍了IgY在水生动物细菌和病毒感染防控、治疗中的潜在应用,为今后IgY的研究和水产养殖中的应用提供参考。

关键词: 卵黄抗体, 被动免疫, 水生动物疾病

CLC Number:

S942.3

ZHENG Jiemin, YOU Jiantao, WU Liang, LIN Jiaming, HE Yibin, XU Bin, XUE Haibo. Research progress on immunoglobulin of yolk in the prevention and treatment of aquatic animal diseases[J]. Journal of Fisheries Research, 2024, 46(2): 190-197.

郑杰民, 游剑涛, 吴亮, 林嘉铭, 何艺宾, 徐斌, 薛海波. 卵黄抗体在水生动物疾病防治中的研究进展[J]. 渔业研究, 2024, 46(2): 190-197.

Figures/Tables 2

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参数Parameters	IgG	IgY
物种Species	哺乳动物	禽类
来源Source	血清	蛋黄
采集方式 Acquisition mode	对动物有伤害	对动物无伤害
抗体总产量(年)/g Amount of antibody(year)	5	17~35
特异性抗体总产量/% Amount of specific antibody	<5	1~10
采集持续时间 Acquisition duration	不连续	连续
分子重量/kDa Molecular weight	150	180
恒定区Constant region	3	4
糖链数量 Amount of sugar chain	1	2
铰链区Hinge region	有	无
补体激活 Activation of complement	有	无
类风湿因子激活 Interference with rheumatoid factor	有	无
Protein A/G绑定 Protein A/G binding	有	无
pH	2.0~11.0	4.0~11.0
热稳定性/℃ Heat stability	30~80	30~70
疏水性Hydrophobicity	弱	强

参数Parameters	IgG	IgY
物种Species	哺乳动物	禽类
来源Source	血清	蛋黄
采集方式 Acquisition mode	对动物有伤害	对动物无伤害
抗体总产量(年)/g Amount of antibody(year)	5	17~35
特异性抗体总产量/% Amount of specific antibody	<5	1~10
采集持续时间 Acquisition duration	不连续	连续
分子重量/kDa Molecular weight	150	180
恒定区Constant region	3	4
糖链数量 Amount of sugar chain	1	2
铰链区Hinge region	有	无
补体激活 Activation of complement	有	无
类风湿因子激活 Interference with rheumatoid factor	有	无
Protein A/G绑定 Protein A/G binding	有	无
pH	2.0~11.0	4.0~11.0
热稳定性/℃ Heat stability	30~80	30~70
疏水性Hydrophobicity	弱	强