关键词: 双斑东方鲀, 药物, 急性毒性, 半致死浓度, 安全浓度, Fugu bimaculatus, drug, acute toxicity, lethal concentration 50 (LC50), safe concentration(SC)

Abstract: The acute toxicity of six common drugs, including potassium permanganate, povidone-iodine, formaldehyde, glutaraldehyde, trichlorfon and cupric acetate, to Fugu bimaculatus were studied at water temperature of (27±1)℃, salinity of 25±1, pH of 7.90~8.10 and dissolved oxygen level of above 6.0 mg/L using static bioassay test. The results showed that the lethal concentration 50 (LC50) of potassium permanganate to F. bimaculatus for 24, 48, 72 and 96 h were 1.88, 1.84, 1.76 and 1.75 mg/L, respectively; the 24, 48, 72 and 96 h LC50 of povidone-iodine were 23.30, 22.55, 20.34 and 19.50 mg/L; the 24, 48, 72 and 96 h LC50 of formaldehyde were 11.27, 7.06, 6.38 and 5.57 mg/L; the 24, 48, 72 and 96 h LC50 of glutaraldehyde were 9.25, 9.03, 7.03 and 5.48 mg/L; the 24, 48, 72 and 96 h LC50 of trichlorfon were 16.85, 14.19, 10.23 and 7.92 mg/L; the 24, 48, 72 and 96 h LC50 of cupric acetate were 10.54, 8.78, 6.13 and 5.46 mg/L. The safe concentration was found to be 0.53 mg/L in potassium permanganate, 6.34 mg/L in povidone-iodine, 0.83 mg/L in formaldehyde, 2.58 mg/L in glutaraldehyde, 3.02 mg/L in trichlorfon and 1.83 mg/L in cupric acetate. Order of sensitivities of six drugs to F. bimaculatus was: povidone-iodine > trichlorfon > glutaraldehyde > cupric acetate > formaldehyde > potassium permanganate. The using of six drugs should be controlled strictly in production according to safe concentration.