ACE抑制肽的制备、构效关系及活性评价研究进展

doi:10.14012/j.cnki.fjsc.2022.01.011

渔业研究 ›› 2022, Vol. 44 ›› Issue (1): 100-108.DOI: 10.14012/j.cnki.fjsc.2022.01.011

• 综述与其他 • 上一篇

ACE抑制肽的制备、构效关系及活性评价研究进展

沈嘉森¹^,²^,³(), 苏永昌³, 林河通¹^,², 李水根⁴, 陈晓婷³, 刘智禹³^,^*()

1.闽台特色海洋食品加工及营养健康教育部工程研究中心,福建福州 350002
2.福建农林大学食品科学学院,福建福州 350002
3.福建水产研究所,国家海水鱼类加工技术研发中心,福建省海洋生物增养殖与高值化利用重点实验室,福建厦门 361013
4.福建海洋职业技术学校,福建福州 350002

收稿日期:2021-05-24 出版日期:2022-02-25 发布日期:2022-02-17
通讯作者: 刘智禹(1972-),男,教授级高工,博士,研究方向:为水产品加工与综合利用研究.E-mail:13906008638@163.com
作者简介:沈嘉森(1996-),男,硕士,研究方向:水产品加工及贮藏工程.E-mail:905505974@qq.com
基金资助:
国家重点研发计划(2018YFD0901102);2020年福建省海洋与渔业结构调整专项(2020HYJG06);福建省省属公益类科研院所基本科研专项(2020R10130015);福建省种业创新与产业化工程(2017FJSCZY03)

Research progress on preparation,purification and structure activity relationship of ACE inhibitory peptide

SHEN Jiasen¹^,²^,³(), SU Yongchang³, LIN Hetong¹^,², LI Shuigen⁴, CHEN Xiaoting³, LIU Zhiyu³^,^*()

1. Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition,Ministry of Education,Fuzhou 350002,China
2. College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China
3. National Research and Development Center for Marine Fish Processing,Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Fisheries Research Institute of Fujian,Xiamen 361013,China
4. Fujian Ocean Vocational and Technical School,Fuzhou 350002,China

Received:2021-05-24 Online:2022-02-25 Published:2022-02-17

摘要/Abstract

摘要：

ACE抑制肽是通过食源性加工制备而成的具有降血压作用的生物活性多肽,包含抗氧化、抗炎、抗肥胖等多种潜在生理活性,将纯化后的多肽序列与ACE相互作用,研究其构效关系。ACE抑制肽具有天然可靠、无毒、安全等优点,在食品工业中受到了广泛的关注和应用。本文概述ACE抑制肽,重点对多肽的制备、分离纯化、分子模拟及原发性高血压大鼠的体内表达和体外功能活性评价等研究进展进行综述,以期为ACE抑制肽在加工和生产领域的进一步开发提供借鉴。

关键词: ACE抑制肽, 分离纯化, 构效关系, 活性评价, 分子模拟

Abstract:

In this study,ACE inhibitory peptide was a biologically active peptide with blood pressure lowering effect prepared by food-based processing.It contained a variety of potential physiological activities such as anti-oxidation,anti-inflammatory,and anti-obesity.The purified peptide sequence was interacted with ACE to study its structure-activity relationship.ACE inhibitory peptide was natural and reliable,non-toxic and safe,gradually replaced artificial chemical antihypertensive inhibitors and had been widely concerned and applied in the food industry.Therefore,to summarize the knowledge of ACE inhibitory peptides,the advances in the preparation,isolation and purification,molecular simulation,in vivo expression of spontaneously hypertensive rats and in vitro functional activity evaluation of polypeptides were reviewed.It is expected to provide valuable reference for the further development of ACE inhibitory peptide in the field of processing and production.

Key words: ACE inhibitory peptides, separation and purification, structure activity relationship, molecular simulation

中图分类号:

S985

沈嘉森, 苏永昌, 林河通, 李水根, 陈晓婷, 刘智禹. ACE抑制肽的制备、构效关系及活性评价研究进展[J]. 渔业研究, 2022, 44(1): 100-108.

SHEN Jiasen, SU Yongchang, LIN Hetong, LI Shuigen, CHEN Xiaoting, LIU Zhiyu. Research progress on preparation,purification and structure activity relationship of ACE inhibitory peptide[J]. Journal of Fisheries Research, 2022, 44(1): 100-108.

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ACE抑制肽的制备、构效关系及活性评价研究进展

Research progress on preparation,purification and structure activity relationship of ACE inhibitory peptide

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