Abstract: Microalgae is a kind of unicellular photosynthetic autotrophic eukaryotic plant, which grows rapidly and processes high photosynthetic efficiency.It can provide a lot of high value products, such as protein, polyunsaturated fatty acids and bioactive compounds which are important sources of health care, aquaculture and biofuels.In order to improve productivity, microalgae breeding technology has been developed to explore the strains which have larger biomass, more lipid, and the ability of stress resistance.The article summarized the advantages and disadvantages of various breeding technologies and research advanced, in order to provide a reference for the development of microalgae breeding.