Abstract: This study investigated the protective effect of oyster extract on acute liver injury in mice. A model of alcohol-induced acute liver injury in mice was established to monitor the body weights of mice,the contents of MDA(Malondialdehyde),GSH(glutathione) and TG(triglycerides) in liver tissues and the effects of liver histopathology. The results showed that there was no significant difference in the weight of mice between all dose groups of oyster extract and model group and normal group(P>0.05). MDA and TG levels in high-dose group were significantly lower than those in model group,and GSH levels in high-dose group were significantly higher than those in model group(P < 0.05). The degree of hepatic steatosis in high-dose group was significantly lower than that in model group,with no significant difference(P < 0.05). Therefore,it could be revealed that oyster extract had an auxiliary protective function on acute chemical liver injury in mice.