Abstract: The drying characteristic,effective diffusion coefficients and mathematical modeling of seahorse vacuum freeze-drying were investigated in the present study.According to kinetics of seahorse for vacuum freeze drying obtained in this study,the weight of seahorse kept stable after drying for twenty-five hours,and effective diffusion coefficients during drying process was 2.442 3×10^-10 m²/s.Through fitting of experimental data to eight thin layer drying models,the results indicated that the Page model was a suitable model for vacuum freeze drying techniques,with correlation coefficient(R²),reduced chi-square(χ²) and root mean square error (RMSE)as 0.999 4,5.961 9×10^-5 and 2.090 0×10^-4,respectively.The results would provide theoretical basis for the production and processing of seahorse drying.