Abstract: Marine shellfish are rich of sources of structurally diverse biofunctional peptides.Researches showed that those biofunctional peptides may significantly promote human health.The bioactive peptides derived from marine shellfish have a variety of physiologic functions, and they have been reported to have antioxidative, antitumor, antihypertension, anticoagulation and anticoagulation activities.Nowadays, more and more domestic and overseas research institutions are interested in the preparation of bioactive peptides from marine shellfish by enzymatic hydrolysis.This review summarizes current technologies used in the preparation, separation and purification technologies of bioactive peptides from marine shellfish.It outlines the activities and methods of structural identification of marine shellfish-derived bioactive peptides.Finally, some questions about the research of bioactive peptides found in marine shellfish are briefly discussed.