Abstract: A feeding experiment was to determine the physiological effects of different feed additives on the growth and digestive enzymes include pepsase, amylase and lipase of Babylonia lutosa. Babylonia lutosa with average initial body mass of （3.99±0.94）g and shell height of （25.58±4.56） mm were divided into S0 group(the control group), S1 group (Chinese medicine group), S2 group (microbial ecological agent group), S3 group (multivitamin group) and S4 group (the mix group, chose one different agent every day). The results showed that: S4 had a highest average body mass by （11.79±0.32）g after experimenting for 40 d, which was 1.32 times higher than S0, different significantly. The digestive enzymes activity had a trend of increasing first and then decreasing, but there was synergy among the digestive enzymes. The effect of additive was more significant in S4, but there was a large fluctuations in S1 and S2, and kept stable in S3. So the experiment showed that S4 had a great effect on growth and digestive enzymes activity, but the effect weakened by the treating time, S1, S2 and S3 are also so. Especially, S1 had a high pepsase activity and S3 had a high lipase activity in the early experiment stage. It showed that low frequency additive adding could promote digestion performance and growth for Babylonia lutosa.