Abstract: The study on new breeding model of ecological optimization and disease control and prevention in Epinephlus coioides has been reported in this article.The research mainly focuses on prevention of nervous necrosis virus (NNV) and so on.These researches include:Firstly,blocking the spread pathways of the virus,such as choosing fertilized eggs carrying no virus,furthermore disinfecting strictly and completely nursery ponds,tools,biological feed and also fertilized eggs before the eggs entering nursery ponds.Secondly,the microecological environment of seedling pools should remain relatively steady and make probiotics become dominant species in the water to consume harmful substances like ammonia nitrogen and so on,and also to control the reproduction of malignant bacteria.Thirdly,it is important to maintain nutrition of the fish fry to improve its physical and health level,to enhance its ability of resisting virus disease,and thus to increase the survival rate of larvae,that more mature and standardized type and proportion of fish bait for the larvae,fry or juvenile have been putted into effect.