Abstract: Base on analyzing main marine exploitation project in San-sha bay, 27 essential factors including topography and geomorphology ,water dynamical environment,water and sediment quality environment,ecological enviorment and the potential incurrence effect on disaster were selected from aspects of types of sea utilizing.Relations among these factors were analysed using interpretative structural modeling method(ISM) to set up the Interpretive Structural Modeling of cumulative ecological effects(CCE) on resources exploitation and utilization in Bay.The model clearly showed CCE occur process of the resource exploitation and utilization in Bay in every level.It offered the theoretical basis and technical method for the govenment planning and management in resources and environment.