Abstract: This paper described the definition and the implementation background of the Laboratory Information Management System (LIMS), and analyzed the problems that the traditional analytical laboratory faced with, such as difficult to improve detection efficiency, difficult to manage logistics affairs, difficult to conduct statistical analysis, and difficult to check sample status and so on. While the LIMS takes the overall environment of analytical laboratory as a management object, improves the overall management of the laboratory work with computer network technology, and compared with traditional manual management mode, it has advantages of scientific management, high detection efficiency, reliable results, greater data security, coordination of all kinds of resources in laboratory and realization of the quantitative management. The paper made preliminary study on the function modules of LIMS from the system architecture, pointed out the lab should be strengthen the team-building, improve the quality of personnel, and standardize management system, take a step-by-step approach to complete a gradual transformation of work mode, so as to realize the efficient development and use of LIMS.