Abstract: The results of research on large-scale artificial breeding technique of Sipunculus nudus from 2008 to 2010 were reported in this paper. A certain amount of Sipunculus nudus parents were collected from the coastal sea along Fujian from March to May each year, and then got fertilized eggs through artificial induced spawning after parents enhancing cultivation. At water temperature of 28.5~30.5℃ and salinity of 26~32, the hatched pelagosphreic larvae were undergone complete metamorphosis of nymph by 9~13days, and became juveniles with the body length of 1.0~2.8cm after more than one month of larvae breeding. We have artificial bred 1779000, 2880000 and 5526000 of Sipunculus nudus juveniles with body length of 1.0~2.8cm in 2008, 2009 and 2011,respectively.