Abstract: In recent years,the incidence of hyperuricemia and gout has risen,and the high level of uric acid often leads to rheumatism,cardiovascular and cerebrovascular diseases,renal dysfunction and a series of complications,which seriously impacts upon people's normal quality of life and social production.Compared with the western medicine currently used in clinical practice,active substances from natural resource get more attention because of the more moderate function,safer,no damage to the kidney,fewer side effect and so on.Various active substances from natural resource which have the uric acid-lowering efficacy reported currently were mainly polysaccharide,polyphenols,saponins,flavonoids,bioactive peptides,etc.This paper reviewed the synthetic pathways of uric acid and the enzymes that play an important role in purine metabolism in human body(such as xanthine oxidase,adenosine deaminase,etc.),uric acid excretion pathway and main influencing factors,the pathogenesis of high uric acid and the reasons for the imbalance of purine metabolism,the common evaluation model of uric acid-lowing,and the research progress of marine natural active substances that have effects of lowering uric acid.And we hoped to provide a reference for the development of functional food with the effect of reducing uric acid.