Abstract: From August to September 2018, 17 oyster samples were selected from 17 major shellfish cultivation areas in 6 coastal cities of Fujian Province. The investigation found that the concentration of Cu and PHCs in oyster samples from some cultured sea areas exceeded the second class marine biological quality standard. The correlation analysis showed that there was a strong positive correlation between Cu and Cd, Pb and PHCs, BHC and PCBs, as well as Cu and PCBs. Through the principal component analysis of the test parameters, the variance contribution rates of the three principal component factors were 29.436%, 24.938% and 15.838% respectively, and the cumulative contribution rate reached 70.211%. Cu, Hg and PCBs were the main driving factors of primary pollutants in oysters from Fujian coast.