Abstract: In order to promote the healthy and sustainable development of culture industry and provide high quality spats of Meretix lyrata, artificial breeding technique in a large scale of M. lyrata was carried out. Unicellular algae were used as feeds during the breeding period. There were 6 batches of 580 kg parental M. lyrata which were artificially induced to spawn. The total number of fertilized eggs were 4.0336 billion, and 2.843 7 billion D-shaped larvae were hatched, so the hatching rate was 70.5%. After 7 days breeding of planktonic larvae, the larvae began to attach with the process of metamorphosis, and 1.515 7 billion attachment larvae were obtained, so the attachment rate was 53.3%. After another 33 days growth, 898.6 million spats with average shell length of 916.17 μm survived, the survival rate of artificial breeding was 31.6%, and the average output of spats per unit was 2.496 million seeds/m2.