海洋贝类Toll样受体及信号通路的研究进展

›› 2016, Vol. 38 ›› Issue (6): 501-509.

海洋贝类Toll样受体及信号通路的研究进展

乔琨¹,陈贝¹,刘智禹¹,方春华²,潘南¹,许旻¹,吴靖娜¹,刘淑集¹

1. 福建省水产研究所
2. 福建水产研究所

收稿日期:2016-10-20 修回日期:2016-10-28 出版日期:2016-12-25 发布日期:2016-12-19
通讯作者: 刘智禹
基金资助:
省属公益类科研院所基本科研专项;福建省海洋生物增养殖与高值化利用重点实验室开放课题;国家海洋公益性行业科研专项;福建省科技重大专项;海洋经济创新发展区域示范项目;福建省海洋经济创新发展区域示范项目;厦门南方海洋研究中心项目

Research progress on the marine shellfish Toll signaling pathway

Received:2016-10-20 Revised:2016-10-28 Online:2016-12-25 Published:2016-12-19

摘要/Abstract

摘要： Toll样受体（Toll-like receptor, TLR) 是模式识别受体家族（PRR）中重要的一员，它可以特异地识别病原体相关的分子模式（PAMP），激活信号级联、诱发固有免疫反应，在抵御病原微生物过程中发挥重要作用。TLRs最早在果蝇胚胎中发现，是ー类进化高度保守的免疫受体家族，在果蝇及脊椎动物中研究得较为透彻。海洋贝类具有较高的经济价值及重要系统进化地位，近年来，大量贝类的Toll样受体及信号通路相关因子被发现。本文综述了 Toll样受体的结构、信号通路和海洋贝类TLR及信号通路相关因子的研究进展，有助于丰富海洋贝类固有免疫理论研究。

关键词: 海洋贝类, Toll样受体, 信号通路, 固有免疫, marine shellfish, Toll-like receptor, signaling pathway, innate immunity

Abstract: Toll-like receptor，an important member of a family of pattern recognition receptors (PRR)，can recognize a variety of pathogen associated molecular patterns and activate signaling cascades to induce innate immunity. Toll - like receptors plays an important role in host defense against microbial pathogens. Toll receptor was originally identified in Drosophila embryos， which was highly conserved families in evolution.Much work has been done on TLRs in Drosophila and vertebrates. Recently， research on mollusk Toll–like receptor and Toll pathway has increased due to its high economic value and the position in phylogenetic research. This review presents the research progress of loll - like receptor and Toll pathway in marine mollusks，which updates the information of innate immunity in marine shellfish.

乔琨陈贝刘智禹方春华潘南许旻吴靖娜刘淑集. 海洋贝类Toll样受体及信号通路的研究进展[J]. , 2016, 38(6): 501-509.